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| The Duodenal Hormone - CCK |
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CCK or Cholecystokinin, the name coined by Ivy and Olberg in 1928,causes the
gallbladder to contract and behaves differently than Secretin in some respects.
CCK was prepared by Ivy, et al in 1929 isolated from the upper intestine of Hog,
Dog, Sheep and cattle. In 1930, Ivy, et al injected human subjects with CCK with
complete or partial evacuation of the gallbladder in 4 out of 5 subjects. Use
of CCK as a therapeutic agent however was questioned since it apparently did
nothing more than egg yolk and cream and fatty meals. The latter produced the
same effect but in a slower manner. Purification of CCK in 1939 by Agren and
subsequent work by Harper in the early 1950's and their "Pancreozymin"
preparations continued the exploration of CCK. Mutt and then Jorpes and Mutt in
the late 50's to early 60's researched the purification of CCK. In 1967 Jorpes
and Mutt delineated the structure of CCK consisting of 33 amino acids.
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| CCK was the defined name in 1964 and 1966 by Jorpes and Mutt when
they described both CCK and Pancrozymin activities and found essentially the
same substance. However, due to differences in terminology in unitages it was
decided that CCK would be the preferred name with Ivy dog units as the base for
activity. In 1968-70 Jorpes and Jutt indicated that the CCK-octapeptide (CCK-8)
showed full potency of total CCK, as did the synthetic and natural octapeptides.
The pancreozymin activity of extracts of the duodenal-jejunal mucosa has been
shown to be due to CCK.
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| In 1975, Dafny, et al administered CCK-8 peripherally and
produced enhancement of acoustical evoked potentials in several regions of rat
brain. In 1979, Della-Fera and Baile inhibited feeding in sheep with CCK-8
intracerebroventricularily. In 1979, Vijayas, et al administered CCK-8 into
the third ventricle of conscious, female, ovariectomized rats and stimulated
prolactin and GH release and inhibited LH and TSH release. In 1982, Sakamoto,
Otsuki, et al., demonstrated that CCK or Caerulein stimulated both insulin
secretions and pancreatic exocrine function if 5.6mM or more of glucose is
present in perfused rat pancreas. Okabayaski, Otsuki, et al.,(1983) in work
with perfused rat pancrease showed that deaminated CK-8 had no effect on
exocrine pancreatic secretion at a concentration of 100pM. C-terminal fragments
of CCK with eight or more amino acid residues were a potent potentiator of
insulin release as well as a pancreatic exocrine stimulant. Spanarkel, et al,
indicate that CCK (27-32) amide antagonized the stimulation caused by CCK
related agonists. In 1984, Beglinger, et al., indicated that (Thr28,
Nle31) CCK (25-33)-"Nona CCK"-, natural porcine CCK(33) and synthetic
Caerulein were found to be equipotent on a molar basis in stimulating exocrine
pancreatic secretion. "Nona CCK" being less susceptible to oxidation than other
CCK's offers interesting thought for medical and biological research.
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| - 43 CCK fragments available - |
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01-7690-02 |
CHOLECYSTOKININ 26-28 desulfated
(Asp-Tyr-Met)
m.w. 427.47
available in 10 & 25 mg quantities |
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01-8268-02 |
CHOLECYSTOKININ 26-28 sulfated
(ASP-TYR(SO3H)-MET.NH3)
m.w. 524.6
C:34.22 H:3.81
N:6.35 S:8.55 Sol: DMSO
available in 10 & 25 mg quantities |
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01-7691-02 |
CHOLECYSTOKININ 26-29 desulfated
(ASP-TYR-MET-GLY)
m.w. 484.52
available in 10 & 25 mg quantities |
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01-2760-02 |
Ac, CHOLECYSTOKININ 26-32
(ACETYL-ASP(Ba/2)-TYR(SO3Ba/2)-MET-GLY-trP-
MET NH2)
m.w. 1058.4
available in 10 & 25 mg quantities |
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03-2761-02 |
CHOLECYSTOKININ 26-32 protected, sulfated S1
(CBZ-Asp-Tyr(SO3H)-Met-Gly-Trp-Met-Asp-NH2)
m.w. 1301.2
available in 10 & 25 mg quantities |
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20-3061-02 |
CHOLECYSTOKININ 26-32
(D-Tyr-Gly-2-Phenylethylester) S3
(D-Tyr-Gly-Asp-Tyr(SO3H)-Nle-Gly-Trp-Nle-Asp-2-
Phenylethylester)
("OPE" analogue) ("D-Tyr-Gly JMV180")
(>85% by HPLC) m.w. 1285.4
available in 1 & 5 mg quantities |
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01-0798-02 |
A
c, CHOLECYSTOKININ 26-33, Sulfated
(ACETYL-ASP-TYR(SO3H)-MET-GLY-trP-MET-ASP-PHE NH2)
m.w. 1236.5
available in 10 & 25 mg quantities |
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01-0323-02 |
CHOLECYSTOKININ-8 26-33, desulfated
(ASP-TYR-MET-GLY-trP-MET-ASP-PHE NH2)
m.w. 1063.17
available in 10 & 25 mg quantities |
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01-0340-02 |
CHOLECYSTOKININ-8 26-33, sulfated
(ASP-TYR(SO3H)-MET-GLY-trP-MET-ASP-PHE
NH2.2NH3)
m.w. 1177.4
available in 1, 5 & 10 mg quantities |
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01-0341-02 |
CHOLECYSTOKININ-8, sulfated, deaminated
(ASP-TYR(SO3H)-MET-GLY-trP-MET-ASP-PHE-OH
.2-3 NH3)
m.w. 1144.3 (w/o NH2)
available in 1 & 5 mg quantities |
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01-0794-02 |
BOC CHOLECYSTOKININ-8
(t-BOC-ASP-TYR(SO3H)-MET-GLY-trP-MET-ASP-PHE
NH2)
m.w. 1294.5
available in 5 & 10 mg quantities |
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02-9880-02 |
CHOLECYSTOKININ "JMV180"
(BOC-TYR(SO3H)-NLE-GLY-trP-NLE-ASP-2-
PHENYLETHYLESTER NH3)
m.w. 1084.3 (Sol:DMSO)
available in 1 & 5 mg quantities |
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02-3060-02 |
CHOLECYSTOKININ 27-32
(Nle28,31)
(BOC-TYR(SO3H)-NLE-GLY-D-trP-LE-ASP-2-
PHENYLETHYLESTER NH3)
(D-Trp "JMV-180")
(D-Trp4)
m.w. 1084.3
available in 1 & 5 mg quantities |
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03-2764-02 |
CBZ CHOLECYSTOKININ-PZ 27-32, desulfated
(CBZ-TYR-MET-GLY-trP-MET-ASP NH2)
m.w. 935.1
available in 10 & 50 mg quantities |
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03-2762-02 |
CBZ-TYR(SO3)-MET-GLY-trP-
MET-ASP NH2 .2NH3
m.w. 1047.2
available in 10 & 50 mg quantities |
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20-2763-02 |
CHOLECYSTOKININ 27-32, sulfated
(L-TYR(SO3)-MET-GLY-trP-MET-ASP NH2)
m.w. 1016.4
available in 10 & 50 mg quantities |
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02-1990-02 |
BOC CHOLECYSTOKININ 27-33
(N-a-t-BOC-L-TYR-MET-GLY-trP-MET-ASP-PHE NH2)
m.w. 1047.29
available in 10 & 25 mg quantities |
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03-2765-02 |
CBZ CHOLECYSTOKININ-PZ 27-33, sulfated, unblocked
(CBZ-TYR(SO3H)-MET-GLY-trP-MET-ASP-PHE OH)
m.w. 1214.4
available in 10 & 50 mg quantities |
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20-7375-02 |
CHOLECYSTOKININ 27-33
(L-TYR-MET-GLY-trP-MET-ASP-PHE NH2)
m.w. 947.07
C:55.96 H:5.95 N:12.99 S:6.62
available in 10 & 25 mg quantities |
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20-6611-02 |
CHOLECYSTOKININ 27-33
(TYR(SO3H)-MET-GLY-trP-MET-ASP-PHE
NH2.NH3)
m.w. 1062.30
available in 10 & 25 mg quantities |
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01-4912-02 |
Ala1-CHOLECYSTOKININ 27-33 desulfated
(L-ALA-TYR(SO3H)-MET-GLY-trP-MET-ASP-PHE NH2)
GAStrIN 11-17 (MET3) SULFATED
m.w. 1116.3
available in 10 & 25 mg quantities |
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02-1991-02 |
BOC-CHOLECYSTOKININ 28-33
(N-a-t-BOC-MET-GLY-trP-MET-ASP-PHE NH2)
m.w. 884.12
available in 10 & 25 mg quantities |
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13-5025-02 |
CHOLECYSTOKININ-PZ 28-33
(L-MET-GLY-trP-MET-ASP-PHE NH2)
m.w. 783.90 C:54.56
H:6.12 N:13.94 S:8.08
available in 10 & 25 mg quantities |
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02-1992-02 |
BOC CHOLECYSTOKININ 29-33
(N-a-t-BOC-GLY-trP-MET-ASP-PHE NH2)
GAStrIN 13-17, BOC PROTECTED
m.w. 752.94
available in 10 & 25 mg quantities |
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07-9992-02 |
CHOLECYSTOKININ 29-33
(GLY-trP-MET-ASP-PHE OH Gastrin 14-17)
m.w. 654.72
available in 10 & 25 mg quantities |
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07-2750-02 |
CAERULEIN 6-10
(Gly-Trp-Met-Asp-Phe-NH2) GAStrIN 13-17
m.w. 652.17
available in 10 & 25 mg quantities |
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02-1993-03 |
BOC CHOLECYSTOKININ 30-33
(N-a-t-BOC-L-trP-MET-ASP-PHE NH2)
(BOC Tetragastrin)
GAStrIN 14-17 BOC protected
m.w. 696.8 [5235-21-2]
available in 10 & 25 mg quantities |
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20-9991-02 |
L-trP-MET-ASP-PHE OH
m.w. 597.68 C:57.94
H:5.85 N:11.58 S:5.41
available in 25 & 100 mg quantities |
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20-7246-02 |
L-trP-MET-ASP-PHE NH2
m.w. 595.56 m.p. 242oC (dec)
C:57.56 H:6.14 N:13.89
S:5.56 [1947-37-1]
available in 50 & 100 mg quantities |
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13-4605-02 |
C-term. of CHOLECYSTOKININ-PZ
(L-MET-ASP-PHE NH2)
m.w. 409.46 C:52.34
H:6.28 N:13.53 S:8.15
available in 25 & 50 mg quantities |
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02-2766-02 |
BOC CHOLECYSTOKININ 31-33
(N-a-t-BOC-MET-ASP-PHE NH2) GAStrIN 15-17
BOC protected
m.w. 509.68
available in 25 & 50 mg quantities |
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01-0963-02 |
CAERULEIN 9-10 GAStrIN 16-17
(a-L-Asp-Phe-NH2)
m.w. 278.28
available in 50 & 100 mg quantities |
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02-1656-02 |
BOC CHOLECYSTOKININ 32-33
(N-a-t-BOC-ASP-PHE-NH2) GAStrIN 16-17 BOC protected
m.w. 387.50
available in 100 & 250 mg quantities |
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02-1655-03 |
BOC CHOLECYSTOKININ 33
(N-a-t-BOC-L-PHE NH2) GAStrIN 17 BOC protected
m.w. 264.30 C:63.29 H:7.65
N:10.44
available in 100 & 250 mg quantities |
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NONA-CHOLECYSTOKININ THR28,
NLE31 (25-33)
(Identical in potency to CCK-33 and pure Caerulein) |
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01-2710-02 |
Nona CHOLECYSTOKININ-Thr28
Nle31
(ARG-ASP-TYR(SO3H)
-THR-GLY-trP-NLE-ASP-PHE NH2)
m.w. 1251.37
available in 1 & 5 mg quantities |
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20-8354-02 |
Nona CHOLECYSTOKININ
TYR-ARG-ASP-
(TYR(SO3H)-THR-GLY-trP-NLE-ASP-PHE-NH2)
(Tyr-Arg1)
m.w. 1431.6
available in 1.0 & 2.5 mg quantities |
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01-2718-02 |
Nona CHOLECYSTOKININ 26-33, sulfated
(ASP-TYR(SO3H)-THR-GLY-trP-NLE-ASP-PHE-
NH2.NH3)
m.w. 1129.2
available in 1 & 5 mg quantities |
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01-2719-02 |
Nona CHOLECYSTOKININ 26-33,
desulfated
(ASP-TYR-THR-GLY-trP-NLE-ASP-PHE-NH2)
m.w. 1015.15
available in 1 & 5 mg quantities |
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20-2720-02 |
Tyr-Nona-CHOLECYSTOKININ 26-33
(TYR-ASP-TYR(SO3H)-THR-GLY-trP-NLE-ASP-PHE-
NH2)
m.w. 1292.4
available in 1 & 5 mg quantities |
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20-2721-02 |
(Tyr-Gly (Nle28,31) -
CHOLECYSTOKININ 26-33)
(D-TYR-GLY-ASP-TYR(SO3H)
-NLE-GLY-trP-NLE-ASP-PHE.NH2.2NH3)
m.w. 1361.5
available in 1 & 5 mg quantities |
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20-2783-02 |
D-TYR-GLY-TYR(SO3H)
-NLE-GLY-trP-NLE-(N-MeASP)-PHE-NH2 S3
m.w. 1225.4
(Label Ready CCK "A" Agonist)
available in 1 & 5 mg quantities |
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02-4910-02 |
t-BOC-ASP(OBut)-TYR-MET-GLY-trP-MET-ASP-PHE-
NH2
m.w. 1219.5
(For Labelling with S35)
available in 25 & 50 mg quantities |
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